21 Oct
UCL Eastman Dental Institute
London
Job description
About the role
The primary role of the Research Fellow will be to execute and lead experimental studies investigating the scale-up and production of allogeneic gene-modified cellular immunotherapies ( allo CAR-T and / or CAR-NK).
This will include the identifying the optimal cell source for allogeneic cellular immunotherapy manufacture, gene-editing / gene delivery for allogeneic applications and development of scalable cell culture processes.
This will include investigating the role of critical process parameters and key variables that impact cell product quality and yield, and require the candidate to have a strong track record in molecular biology, experimental design and bioprocessing.
The candidate will be required work independently to prepare and conduct rigorous and scientifically robust research. The role will require an awareness of current Good Manufacturing Practice (cGMP) as required by health regulators as well as a strong understanding of the commercial and regulatory implications of the work.
With respect to T and / or NK-cell bioprocessing, it is expected the candidate will be familiar with the fundamental biology and simplifying and optimising the isolation of these cells in addition to their upstream / downstream processing, characterisation and cell analysis.
In addition to leading their own research plan, the role will provide significant management and industrial engagement opportunities.
The Research Fellow will support the management of the CGTB Group, including support of the doctoral students and liaising with external partners.
About you
To succeed in this role you will have :
- A PhD awarded (or about to be) in a relevant subject. This may include biological sciences,
cell biology or immunology disciplines, biotechnology or biochemical engineering with relevance to cell culture, bioprocessing and analytics, and an interest in developing an understanding of scalable manufacture of allogeneic cellular immunotherapies.
- Experience immune cell culture and analytics for cellular immunotherapy applications.
- Training and experience in working in cell process development including the use of bioreactors.
- Experience with cell characterisation assays including flow cytometry, ELISA, qPCR and other relevant assays for cellular immunotherapies.
What we offer
As well as the exciting opportunities this role presents, we also offer some great benefits some of which are below :
- 41 Days holiday (27 days annual leave 8 bank holiday and 6 closure days)
- Additional 5 days’ annual leave purchase scheme
- Defined benefit career average revalued earnings pension scheme (CARE)
- Cycle to work scheme and season ticket loan
- Immigration loan
- Relocation scheme for certain posts
- On-Site nursery
- On-site gym
- Enhanced maternity, paternity and adoption pay
- Employee assistance programme : Staff Support Service
- Discounted medical insurance
▶️ Research Fellow in Molecular Biology and Bioprocessing of Cellular Immunotherapies
🖊️ UCL Eastman Dental Institute
📍 London