16 Oct
The Institute of Cancer Research
Sutton
Job description
We are seeking to appoint a Postdoctoral Training Fellow within the Centre for Protein Degradation to work on discovery and validation of novel molecular glue and PROTAC targets and E3 ligases for challenging oncology indications and contribute to our drug discovery projects.
Key Requirements
This position is suitable for a strong team player passionate about innovative solutions for cancer drug discovery. They must have a PhD and should have a solid background in cancer cell and molecular biology, and hands-on experience in cell biology and in vitro genetic manipulation techniques applicable for target validation and interrogation of cell signalling pathways.
Experience in targeted protein degradation,
biochemical and pharmacology assays would be an additional advantage.
Eligibility : The ICR has a workforceagreement stating that Postdoctoral Training Fellows can only be employed for up to 7 years as PDTF at the ICR, providing total postdoctoral experience (including previous employment at this level elsewhere) does not exceed 10 years.
More information about postdoctoral training at The ICR can be found here.
Department / Directorate Information :
This position will be based in the ICR Centre for Protein Degradation - a part of the ICR Centre for Cancer Drug Discovery (CCDD) specialising in developing novel drug modalities that re-wire tumour cells' signaling by targeted degradation of key oncogenic drivers.
Our experienced biologists work closely with medicinal chemists, biophysicists, computational scientists and oncology specialists on expanding the repertoire of novel degradable drug targets and E3 ligases (enzymes that mediate protein degradation),
identifying drugs using innovative screening platforms and characterising their mechanisms of action.
Our research provides a nucleus for other teams internally and externally to explore the therapeutic potential of targeted protein degradation medicines.
Together with the ICR academics, ICR CCDD and collaborations with pharmaceutical industry we develop these rapidly from the laboratory hypothesis-testing to early clinical trials, for the benefit of cancer patients.
We encourage all applicants to look at the attached job pack for more detailed information about this role. For an informal discussion about the role please feel free to contact Dr Agnieszka Konopacka,
Group Leader, Induced Proximity Therapeutics, Centre for Protein Degradation, via email : [email protected]
▶️ Postdoctoral Training Fellow, Target andLigase Discovery, Biology, CPD
🖊️ The Institute of Cancer Research
📍 Sutton